By Qingming Luo, Lihong V. Wang, Valery V. Tuchin

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Extra resources for Advances in Biomedical Photonics and Imaging: Proceedings of the 6th International Conference on Photonics and Imaging in Biology and Medicine (Pibm 2007) Wuhan, P R China, 4-6 November 2007

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51. O. Gollnick, L. W. Henderson, Cancer Res. 62, 1604 (2002). 52. M. Star, Phys. Med. Biol. 42, 763 (1997). 53. S. C. Wilson BC, In The modern technology of radiation oncology, Chp 23, Medical Physics Publishing, Madison, (1999). 54. AAPM Report No. 88, Photodynamic therapy dosimetry, AAPM task group report of the general medical physics committee of the science council. Medical Physics Publishing, (2005). 55. C. S. Patterson and L. Lilge, Lasers Med. Sci. 12, 182 (1997). 56. J. J. S. C. Wilson, Cancer Res.

Furthermore, as a general purpose CMOS image sensor is used, the capabilities and specifications of the camera are set by the manufacturer. A custom made camera design offers several advantages over commercial cameras as the specifications can be tailored to the signals of interest. An important advantage of custom made sensors is that on-chip processing allows the data bottleneck that exists between the photodetector array and processing electronics to be overcome, as the processed data can be read out from the image sensor to a PC or display at a low data rate.

To reach this goal entails a full understanding of the distribution of light, drug, and oxygen in the target tissue. 55 Each class has its own intrinsic merits and limitations. At present, there is no single dose metric that can address all dosimetry problems. Choice of dosimetry depends on the type and location of tumor, type and characteristic of drug and light, desired accuracy and instrumentation complexity, etc. (i) Direct dosimetry uses singlet oxygen (1O2), the putative toxic agent, as PDT dose metric.

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